| ncRNA name | hsa-miR-485 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples and cell lines |
| Methods | qRT-PCR, CCK-8 assay, flow cytometriy, transwell assay, xenograft, luciferase reporter assay, Western blot |
| Expression pattern | down-regulated |
| Functional description | A marked downregulation of miR‑485 expression in human RB tissues and cell lines was observed. miR‑485 overexpression suppressed RB cell proliferation, induced cell apoptosis, attenuated cell migration and cell invasion in vitro, and restrained the growth of RB cells in vivo. Wnt3a was revealed to be a direct target gene of miR‑485 in RB cells. |
| PubMed ID | 30896857 |
| Year | 2019 |
| Title | microRNA‑485 inhibits the malignant behaviors of retinoblastoma by directly targeting Wnt3a. |
| Drug-related ncRNA | NO |
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